Empress Divine DNA Renewal (PDRN, Polydeoxyribonucleotide)
PDRN (polydeoxyribonucleotide) is a purified DNA fragment derived from salmon, selected because its molecular structure is highly compatible with human tissue. At The Empress LA we use VAMP, a high-purity PDRN formulation, delivered into the skin through microneedling. PDRN acts on fibroblasts to support collagen and elastin production, improve hydration by binding water within the tissue, and reduce inflammation. Because it works by supporting the skin's own repair processes rather than adding volume, results develop gradually over several weeks. This treatment is commonly used for acne scarring, dullness, fine lines, under-eye texture, and skin affected by chronic inflammation. A course of three treatments spaced two to three weeks apart is typical.
HOW IT WORKS
Your face is cleansed, numbed, and prepped for microneedling. Ultra-fine needles create microchannels in the skin, which are then infused with VAMP, a high-potency PDRN serum. These microchannels allow the PDRN to reach the dermis, where it activates wound-healing pathways, increase collagen production, and support cellular repair. Over a series of treatments, the skin becomes firmer, brighter, smoother, and more elastic.
WHAT TO EXPECT
Your appointment takes about 60 to 75 minutes, including skin prep, numbing, microneedling, and a calming mask or LED session afterward. Immediately after, the skin usually looks flushed. Over the next 3 to 7 days you may notice dryness, tightness, or light flaking as the skin turns over. Results begin to appear after the first week and continue to develop over the following 3 to 4 weeks as cellular repair progresses. A series of 3 to 4 sessions spaced 4 weeks apart is recommended.
FAQs
How much treatment will I need?
A series of 3 to 4 treatments spaced 4 weeks apart is typically recommended for optimal results.
Most patients notice improvement after the first session, including better hydration, reduced reactivity, and a subtle brightening. PDRN works at the cellular level to support long-term regeneration and collagen synthesis, so results build progressively with each treatment. After the initial series, maintenance every 6 to 12 months helps preserve results.
Does it hurt?
Discomfort is minimal. A topical numbing cream is applied before treatment. Most patients describe the sensation as light pressure or a gentle vibration.
What's the Downtime?
Downtime is minimal. You may look flushed immediately after treatment. Mild redness, dryness, or light peeling can follow for 2 to 5 days and is manageable with hydration and gentle skincare.
How long will it last?
Results are both immediate and progressive. After your first session, skin looks more hydrated and calm. With each treatment, deeper regeneration occurs, improving texture, tone, and elasticity. Thanks to the long-acting nature of PDRN, results can last 6–12 months, depending on your skin’s condition, lifestyle, and maintenance. Annual touch-ups may be recommended for sustained rejuvenation.
Are there any side effects?
Most patients have only mild, temporary side effects such as redness, swelling, or dryness, which usually resolve within a few days. Pinpoint bruising or sensitivity occurs less commonly in more reactive areas.
What should I know before my appointment?
Arrive with clean, makeup-free skin. Avoid retinoids, exfoliants, and acids for 3 to 5 days beforehand, and stop blood-thinning supplements such as fish oil and vitamin E, and NSAIDs, unless they are prescribed. Avoid alcohol for 24 hours before your session to reduce the risk of bruising and inflammation. Stay hydrated and well rested.
What should I know for after my appointment?
Disclaimer: This information provided is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this content is not meant to diagnose, treat, cure, or prevent any disease. You are advised to consult with a qualified healthcare professional for any medical concerns. Use of this information is at your own risk. We are not responsible for any adverse effects, or consequences resulting from the use of any suggestions or information provided.